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FODZYME
FODZYME

1301 reviews

Tasteless add-to-any-food enzyme powder clinically validated to provide relief from FODMAP-related:

bloating
gas
diarrhea
constipation
abdominal discomfort

Ingredients: Enzyme blend (fructan hydrolase, alpha-galactosidase, lactase), dextrin (from non-GMO corn)
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Nutrition Facts

FODZYME® is formulated as a powder to ensure maximum contact between its digestive enzymes and FODMAP-containing foods, allowing for more effective breakdown of FODMAPs during digestion. Unlike capsules, the powder mixes directly with food, optimizing enzyme performance and supporting better digestive relief.

Our formulation consists of clinically and scientifically studied microbial enzymes characterized at both academic institutions, and research partners.
How to use
Step 1

Allow hot foods to cool slightly before applying (below 140 °F / 60 °C).

Step 2

Mix directly or apply evenly on meals. It’s tasteless.

Step 3

Can’t mix? Sprinkle and chew with first bite.

Step 4

Double dose if extra sensitive or for large meals.
Ingredients

Fructan Hydrolase:One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.

Alpha-galactosidase:Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.

Lactase:Simplifies the digestion of lactose, commonly found in dairy products.

Dextrin:Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.

Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.

In Stock
Ships in 1-2 business days
30-day risk-free guarantee.
Free U.S. Shipping. International shipping available.
Complimentary onboarding call.

How It Works

Step 1

Allow hot foods to cool slightly before applying (below 140 °F / 60 °C).

Step 2

Mix directly or apply evenly on meals. It’s tasteless.

Step 3

Can’t mix? Sprinkle and chew with first bite.

Step 4

Double dose if extra sensitive or for large meals.

Why Members
Love FODZYME®

Read all reviews
"It took a few but Fodzyme was able to restore my gut’s balance so that I don’t need Miralax to have regularity."
Chari
"FODZYME makes my life more normal again. I don’t avoid and/or dread eating out anymore. I can travel with less stress."
Brooke H.
"It has changed my life! I can eat foods I have eaten in years! It really works!"
Denise H.
"So helpful to take the stress out. Now I don't bloat and I don't have discomfort after eating. And meals are blissfully not stressful!"
Madeline H.
Read all reviews
10871340

Meals Made Painless

Science-Backed difference

90%

Of the fructan mass broke down within 30 minutes in simulated gastric conditions.1*

84.5%

Of members reported an improvement in bloating after using FODZYME® for 4 weeks.2*

78.2%

Of members said they would be disappointed if FODZYME® ceased to exist.3*

Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)

Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)

FODZYME® was tested in SHIME®, a scientifically validated model of human digestion, to measure its efficacy. Unlike a low FODMAP diet that depletes beneficial short-chain fatty acids (SCFAs), FODZYME® limited but did not eliminate SCFA production, supporting colonic health while easing symptoms 1.

Diagram of SHIME
  1. Kenny Castro Ochoa, Samant S, Liu A, et al. In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment. Gastro Hep Advances. 2022;2(3):283-290. doi:https://doi.org/10.1016/j.gastha.2022.10.011
  2. Based on a survey including n=174 FODZYME® customers evaluating self-perceived efficacy.
  3. Based on a survey including n=220 FODZYME® customers evaluating self-perceived efficacy.
  1. Kenny Castro Ochoa, Samant S, Liu A, et al. In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment. Gastro Hep Advances. 2022;2(3):283-290. doi: https://doi.org/10.1016/j.gastha.2022.10.011
  2. Based on a survey including n=174 FODZYME® customers evaluating self-perceived efficacy.
  3. Based on a survey including n=220 FODZYME® customers evaluating self-perceived efficacy.
Hand pouring FODZYME from a packet Hand pouring FODZYME from a packet

Feel The Difference With Your First Meal

Mix directly or apply evenly on meals.
Double dosage when feasting. Chew well. Enjoy.

Unlock New Foods

Our current formula effectively breaks down the FODMAPs fructan (e.g., garlic, onion, wheat, ...), GOS (e.g., legumes, nuts), and lactose (e.g., dairy products). We are actively developing a solution for polyols (e.g., apple, avocado, mushrooms) such as sorbitol and mannitol.

** FODZYME® significantly reduces fructan (a FODMAP) in wheat, barley and rye products, not gluten. Fructan is often the real trigger in individuals with non-celiac gluten sensitivity.

Learn more

Unlock all the healthy FODMAP foods

FODZYME® can help unlock a long list of healthy, nutritious and delicious foods like,

<p>Wheat bread **</p>

Wheat bread **

<p>Onion</p>

Onion

<p>Garlic</p>

Garlic

<p>Banana</p>

Banana

<p>Wheat pasta **</p>

Wheat pasta **

<p>Artichoke</p>

Artichoke

<p>Cream cheese</p>

Cream cheese

<p>Ice cream</p>

Ice cream

<p>Dairy milk</p>

Dairy milk

<p>Brussels sprouts</p>

Brussels sprouts

<p>Lentils</p>

Lentils

<p>Cashews</p>

Cashews

<p>Scallions</p>

Scallions

<p>Leek</p>

Leek

<p>Beetroot</p>

Beetroot

And many more delicious and nutritious foods

** FODZYME® significantly reduces fructan (a FODMAP) in wheat, barley and rye products, not gluten. Fructan is often the real trigger in individuals with non-celiac gluten sensitivity.

Learn more

Unlock all the healthy FODMAP foods

In Control,
Wherever You Are.

FODZYME®
Home Kit

Sustainable jar. Ideal for home-cooked meals.

FODZYME®
Home Kit

Sustainable jar. Ideal for home-cooked meals.

Tasteless Formulation

FODZYME® is formulated as a tasteless powder to ensure maximum contact between its digestive enzymes and FODMAP-containing foods, allowing for more effective breakdown of FODMAPs during digestion. Unlike capsules, the powder mixes directly with food, optimizing enzyme performance and supporting better digestive relief.

Our formulation consists of clinically and scientifically studied microbial enzymes characterized at both academic institutions, and research partners.

ACTIVE INGREDIENTS:

ENZYME BLEND (32MG PER G) 

<p>Our fructan hydrolase is the first ever enzyme to target fructans like inulin, fructo-oligosaccharides (FOS), and levan.</p>

Our fructan hydrolase is the first ever enzyme to target fructans like inulin, fructo-oligosaccharides (FOS), and levan.

<p>Our alpha-galactosidase enzyme can effectively break down the galacto-oligosaccharides (GOS) or galactans (“O” in FODMAPs).</p>

Our alpha-galactosidase enzyme can effectively break down the galacto-oligosaccharides (GOS) or galactans (“O” in FODMAPs).

<p>Our lactase enzyme (also called β-D-galactosidase) can break down lactose (the “D” in FODMAPs).</p>

Our lactase enzyme (also called β-D-galactosidase) can break down lactose (the “D” in FODMAPs).

Other ingredients: dextrin (from non-GMO corn)
Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.

<p>Soy-free</p>

Soy-free

<p>Egg-free</p>

Egg-free

<p>Non-GMO</p>

Non-GMO

<p>Casein-free</p>

Casein-free

<p>Gluten Free</p>

Gluten Free

<p>No artificial flavors</p>

No artificial flavors

<p>Dairy-free</p>

Dairy-free

<p>Kosher</p>

Kosher

<p>Vegan</p>

Vegan

<p>FDA-Registered Facility</p>

FDA-Registered Facility

<p>Soy-free</p>

Soy-free

<p>Egg-free</p>

Egg-free

<p>Non-GMO</p>

Non-GMO

<p>Casein-free</p>

Casein-free

<p>Gluten Free</p>

Gluten Free

<p>No artificial flavors</p>

No artificial flavors

<p>Dairy-free</p>

Dairy-free

<p>Kosher</p>

Kosher

<p>Vegan</p>

Vegan

<p>FDA-Registered Facility</p>

FDA-Registered Facility

Not a Probiotic.
Not a Pill.

Engineered specifically to break down FODMAPs
Patent-pending formula with first-ever fructan-targeting enzyme.

Powder form for superior efficacy
Powder format allows the enzymes to mix directly with food.

Scientifically validated
Backed by peer-reviewed scientific publications, demonstrating its effectiveness.

Rigorously tested
Third-party tested for enzyme activity, allergens, and contaminants.

Certified low-FODMAP

Hi 👋, We’re
Co-Founders
Anjie and David!

Anjie Liu
Anjie created FODZYME® after battling IBS and the limitations of a low-FODMAP diet. A Harvard-trained physicist and Forbes 30 Under 30 honoree, she leads with a personal mission: to help people enjoy food without fear.
David Hachuel, MPH
David brings deep experience in gut health technology, including founding auggi.ai (acquired by Seed Health). With degrees from Harvard, NYU, and Cornell, he drives FODZYME®’s science, product, and growth to make digestive freedom a reality.

Our Scientific Advisory Board Includes Experts In Gastroenterology, Biotechnology, Computational Biology, And Nutrition, Representing World-Class Institutions.

William D. Chey, MD
Advisor, Professor of Gastroenterology at the University of Michigan and Board member at the American College of Gastroenterology (ACG) and Rome Foundation
Shalaka Samant, PhD
Founding Scientist at Kiwi Biosciences, former postdoctoral researcher at the Yale University School of Medicine
Thomas Wallach, MD
Advisor, Assistant Professor at SUNY Downstate Medical Center, Pediatric Gastroenterology
Jocelyn Wells, MS, RDN
A dietitian with a Master's in Clinical Nutrition, Jocelyn leads FODZYME®'s healthcare partnerships. She bridges the latest research in digestive health and nutrition guidelines to help clinicians bring digestive relief to patients navigating IBS and FODMAPs.

Frequently Asked Questions

What exactly is FODZYME®?

FODZYME®is a tasteless enzyme powder designed to break down FODMAPs (fructan, GOS, and lactose) in food to make meals more digestible. It's formulated specifically for people with FODMAP sensitivities.
What ingredients does FODZYME® contain?
  • Fructan Hydrolase:One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.
  • Alpha-galactosidase:Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.
  • Lactase:Simplifies the digestion of lactose, commonly found in dairy products.
  • Dextrin:Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.

Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.
Is FODZYME® allergen-friendly?

Yes, FODZYME® is:

  • Certified low FODMAP by Monash University and FODMAP Friendly
  • Vegan-friendly
  • Non-GMO
  • Gluten-free
  • Dairy-free
  • Soy-free
  • Egg-free
  • Casein-free
  • Free from artificial colors and flavors
  • Manufactured in the USA with global ingredients
  • Certified Kosher by Kosher Supervision of America (KSA)
What foods does FODZYME® help digest?

FODZYME® targets three primary FODMAP groups—fructans, galacto-oligosaccharides (GOS), and lactose—which are common triggers for digestive discomfort. Its enzyme blend works on foods like garlic, onions, wheat, beans, lentils, dairy products, and certain vegetables, breaking these FODMAPs into easily digestible sugars.

Key Food Groups Supported and Example Foods:

  • Fructans:Garlic, onions, leeks, wheat, barley, asparagus, artichokes, Brussels sprouts, and cashews.
  • GOS:Chickpeas, lentils, black beans, red kidney beans, soy milk (whole bean), pistachios, and oats.
  • Lactose:Milk, yogurt, ice cream, soft cheeses (ricotta, cottage cheese), and cream.
How do I take FODZYME®?
  1. Mix Directly:Mix FODZYME® directly or apply evenly on meals. It’s tasteless.
  2. Alternate Method:If you can’t mix, sprinkle FODZYME® and chew with the first bite.
  3. Adjust Dosage:Dosage is personal—double the dose if extra sensitive or for large meals.
  4. Temperature Note:Allow hot foods to cool slightly before applying (below 140 °F / 60 °C). As a rule of thumb, adding FODZYME® is okay if the meal is cool enough that it won’t burn.
  5. Enjoy:Chew well and enjoy your meal!
How is FODZYME® different from other digestive enzymes?

FODZYME® is the first enzyme blend custom-made to tackle FODMAPs—the fermentable carbs that wreak havoc on sensitive tummies. Its secret sauce is fructan hydrolase, a unique enzyme that breaks down problematic fructans in garlic, onions, and wheat, while lactase and alpha-galactosidase cover a broad range of FODMAP offenders.

Offered in a powdered form for immediate action, FODZYME® mixes instantly with your food—cutting down FODMAP content by up to 90% and easing symptoms like bloating and gas. It’s Monash University-certified and backed by clinical trials, making it a science-driven solution for those seeking real dietary freedom.
How quickly does FODZYME® work? When will I feel something?

FODZYME® begins breaking down FODMAPs immediately upon contact with food. In simulated gastric conditions, it degraded up to 90% of FODMAPs like fructans within 30 minutes. This rapid action prevents undigested FODMAPs from reaching the colon, where they typically ferment and cause symptoms such as bloating and gas.

Most users report symptom relief 4–8 hours after consuming a FODMAP-rich meal—aligned with the time it takes for digested food to reach the colon.
Can I use FODZYME® every day?

Yes, FODZYME®is designed for safe daily use. Its enzymes are naturally occurring and work specifically on FODMAPs without interfering with normal digestion or nutrient absorption. Regular use can help manage symptoms and expand dietary choices for those following a low FODMAP diet.
Will FODZYME® interfere with my medications?

FODZYME® is generally considered safe to use alongside most medications, as its enzymes work specifically on FODMAPs in the digestive tract. However, it’s always a good idea to consult your healthcare provider or pharmacist before starting any new supplement—especially if you’re taking prescription medications.

Individual responses can vary. If you notice any unusual symptoms or changes in medication effectiveness, discontinue use and consult your healthcare provider immediately.
Is FODZYME® a cure for conditions like Irritable Bowel Syndrome (IBS)?

No, FODZYME®is not a cure for IBS or any other digestive disorder. It is a digestive aid designed to help manage symptoms associated with FODMAP sensitivity, common in IBS patients. While it may significantly reduce symptoms like bloating, gas, and abdominal pain, it does not address the underlying causes of IBS or other gastrointestinal conditions. Instead, view FODZYME®as a tool to help manage symptoms and improve quality of life.
Why is FODZYME® a powder instead of a capsule?

FODZYME®’s powdered format mixes directly with your food for instant action on FODMAPs—no waiting for a capsule to dissolve. This allows for:

  • More immediate breakdown of problematic carbs.
  • Flexible dosing based on your meal’s FODMAP content.
  • Even distribution for better overall effectiveness in reducing digestive discomfort.
Is FODZYME® safe to take while I'm pregnant or breastfeeding?

FODZYME®’s enzymes work on your food without entering your body, making it a low-risk option. However, because studies on pregnant or breastfeeding women are limited for ethical reasons, there’s no concrete evidence it’s unsafe—but it’s best to consult your physician before use.

Keep in mind that a low FODMAP diet isn’t generally advised during pregnancy due to potential nutritional restrictions, so always prioritize a nutrient-rich diet. Rest assured that all ingredients are GRAS-certified and undergo rigorous third-party testing for safety and quality.
What does my subscription to FODZYME® include?

A FODZYME® subscription provides flexibility and savings by offering:

  • Home Kit:A 60-dose jar for everyday use.
  • On-the-Go Kit:30 single-serve packets for portability.

You also have the option to subscribe to both. Subscribers receive a $15 discount on all orders, along with the ability to adjust delivery frequency, skip shipments, or cancel anytime.
What is your 30-day risk-free guarantee? Do you accept returns?

If you are not satisfied with your purchase for any reason, you may request a refund within 30 days of delivery of your first order. You’ll receive a full refund for the product cost—less shipping, VAT, and duties—no questions asked.

If you are on a FODZYME® subscription plan, you may reschedule, pause, or cancel anytime.

Please note: Refunds apply to your first order only, not any subsequent shipments.
Do you ship internationally?

Yes! We ship to the following countries:

  • United States
  • Australia
  • New Zealand
  • United Kingdom
  • Canada
  • Belgium
  • Netherlands
  • Poland
  • Austria
  • Germany
  • Czechia
  • Slovakia
  • Switzerland
  • United Arab Emirates
  • Israel
  • France
  • Denmark
  • Italy
  • Finland
  • Norway
  • Sweden

Fructan (a FODMAP) rather than gluten (not a FODMAP) might be the real trigger for those with non-celiac gluten sensitivities.

FODZYME® is gluten-free but does not break down gluten, the protein found in wheat, barley, and rye. However, these grains are also high in the FODMAP fructan, which can cause digestive discomfort for many. In fact, many non-celiacs and individuals without wheat allergies who believe they are sensitive to gluten may actually be reacting to fructans. For those with fructan intolerance, FODZYME® can help improve tolerance to fructan-rich grains like wheat, making them easier to enjoy.

  1. Leibniz-Institut für Lebensmittel-Systembiologie an der TU München. (2020, August 11). Gluten in wheat: What has changed during 120 years of breeding?. ScienceDaily. Retrieved July 19, 2021 from www.sciencedaily.com/releases/2020/08/200811120112.htm
  2. Fedewa, A., & Rao, S. S. (2014). Dietary fructose intolerance, fructan intolerance and FODMAPs. Current gastroenterology reports, 16(1), 370. https://doi.org/10.1007/s11894-013-0370-0 – 4
  3. Schuppan, D., Pickert, G., Ashfaq-Khan, M., & Zevallos, V. (2015). Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best practice & research. Clinical gastroenterology, 29(3), 469–476. https://doi.org/10.1016/j.bpg.2015.04.002
  4. Nordin E., Brunius C., Landberg R., Hellström P.M. Fermentable Oligo-, Di-, Monosaccharides, and Polyols (FODMAPs), but Not Gluten, Elicit Modest Symptoms of Irritable Bowel Syndrome: A Double-Blind, Placebo-Controlled, Randomized Three-Way Crossover Trial. Am. J. Clin. Nutr. 2022;115:344–352. doi: 10.1093/ajcn/nqab337.
  5. Skodje G.I., Sarna V.K., Minelle I.H., Rolfsen K.L., Muir J.G., Gibson P.R., Veierød M.B., Henriksen C., Lundin K.E.A. Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity. Gastroenterology. 2018;154:529–539.e2. doi: 10.1053/j.gastro.2017.10.040.
  6. Lee AR, Wolf RL, Lebwohl B, Ciaccio EJ, Green PHR. Persistent Economic Burden of the Gluten Free Diet. Nutrients. 2019;11(2):399. Published 2019 Feb 14. doi:10.3390/nu11020399
  7. Liu, J., Chey, W. D., Haller, E., & Eswaran, S. (2020). Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn. Annual review of medicine, 71, 303–314. https://doi.org/10.1146/annurev-med-050218-013625
  8. Van den Houte K, Colomier E, Routhiaux K, et al. Efficacy and findings of a blinded randomized reintroduction phase for the low FODMAP diet in Irritable Bowel Syndrome. Gastroenterology. Published online February 22, 2024. doi:10.1053/j.gastro.2024.02.008.
  9. Barone, M., Gemello, E., Viggiani, M. T., Cristofori, F., Renna, C., Iannone, A., Di Leo, A., & Francavilla, R. (2020). Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial. Nutrients, 12(3), 705. https://doi.org/10.3390/nu12030705