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FZ-POL-JAR-120CT - PRS - 01 Polyol Relief Synbiotic - FODZYME
PRS-01 Polyol Relief Synbiotic

Ingredients:

$180.00
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Why a synbiotic

PRS-01™ is formulated as a delayed-release capsule to ensure its ingredients bypass stomach acid and reach the colon intact — where they can support the gut microbiome and do their work effectively. Each plant-based capsule is acid-resistant, delivering its probiotic, prebiotic, and postbiotic payload directly to the large intestine.

Our formulation is built on emerging microbiome science around polyol metabolism, combining clinically studied ingredients selected for their roles in butyrate production and gut microbiome restoration.
How to use

Take 2 capsules daily with water, with or after a meal.

Use consistently — daily intake is key to building polyol tolerance.

If you're on antibiotics, take PRS-01 at least 2 hours before or after your antibiotic dose.

One 8-week course. The goal is to rebuild your tolerance — then move on.
Ingredients

Clostridium butyricum: A probiotic known to support butyrate production in the colon — a key short-chain fatty acid linked to polyol metabolism and gut barrier health.

Corebiome®: A postbiotic form of tributyrin that delivers butyrate directly to the colon, supplementing what your gut bacteria produce naturally.

Livaux®: A low-FODMAP prebiotic fiber derived from whole New Zealand Gold kiwifruit, shown to support the growth of beneficial bacteria including butyrate producers.

Contains no dairy, gluten, soy, animal-derived ingredients, or artificial colors or sweeteners.

In Stock
Ships in 1-2 business days
30-day risk-free guarantee.
Free U.S. Shipping. International shipping available.

Hi 👋, We’re
Co-Founders
Anjie and David!

Anjie Liu
Anjie created FODZYME® after battling IBS and the limitations of a low-FODMAP diet. A Harvard-trained physicist and Forbes 30 Under 30 honoree, she leads with a personal mission: to help people enjoy food without fear.
David Hachuel, MPH
David brings deep experience in gut health technology, including founding auggi.ai (acquired by Seed Health). With degrees from Harvard, NYU, and Cornell, he drives FODZYME®’s science, product, and growth to make digestive freedom a reality.

Our Scientific Advisory Board Includes Experts In Gastroenterology, Biotechnology, Computational Biology, And Nutrition, Representing World-Class Institutions.

William D. Chey, MD
Advisor, Professor of Gastroenterology at the University of Michigan and Board member at the American College of Gastroenterology (ACG) and Rome Foundation
Shalaka Samant, PhD
Founding Scientist at Kiwi Biosciences, former postdoctoral researcher at the Yale University School of Medicine
Thomas Wallach, MD
Advisor, Assistant Professor at SUNY Downstate Medical Center, Pediatric Gastroenterology
Jocelyn Wells, MS, RDN
A dietitian with a Master's in Clinical Nutrition, Jocelyn leads FODZYME®'s healthcare partnerships. She bridges the latest research in digestive health and nutrition guidelines to help clinicians bring digestive relief to patients navigating IBS and FODMAPs.

Frequently Asked Questions

What is a synbiotic supplement?

A synbiotic combines probiotics (beneficial live bacteria) with prebiotics (the fibers they feed on). The goal is to support your gut microbiome in a more complete and synergistic way.
Who can take this supplement?

Individuals experiencing symptoms of bloating, pain, flatulence and diarrhea after consuming polyol-rich foods such as broccoli, apples, peaches, cherries, avocados, mushrooms can use this supplement. It is designed to improve the gut’s inherent capacity to metabolize dietary polyols better and tackle the resulting symptoms.

How can this synbiotic help with polyol intolerance?

Polyol intolerance is linked to reduced levels of specific butyrate- producing gut bacteria that help digest sugar alcohols like sorbitol, mannitol, and xylitol. This synbiotic is designed to:

  • Rebuild butyrate-producing bacterial populations
  • Enhance polyol-degrading enzyme activity
  • Support smoother digestion of polyol-rich foods

With consistent use, this can help reduce bloating, discomfort, and irregularity after eating foods like apples, cherries, avocados, and mushrooms.
What ingredients are in the formulation? Where do they come from?

Each capsule contains:

  • Clostridium butyricum – a probiotic known to support butyrate production
  • Corebiome® – a postbiotic form of butyrate (a gut-friendly short chain fatty acid) that reaches the colon
  • Livaux® – a low-FODMAP prebiotic fiber derived from whole New Zealand Gold kiwifruit

All three work together to support the growth of polyol-degrading bacteria, help rebuild your gut’s capacity to tolerate polyols, and boost overall digestive balance.
Is it recommended to limit/avoid polyol-rich foods while using this synbiotic?

The polyol synbiotic is designed to support the digestion of polyols by helping establish a favorable gut environment. During this gut conditioning phase, stopping the intake of polyol-rich foods may help minimize unnecessary digestive challenges while the microbiome adapts.
Will the ingredients survive stomach acid and reach the colon?

Yes. Each capsule is plant-based, acid-resistant, and designed with delayed-release technology. This ensures the ingredients bypass harsh stomach acid and are delivered intact to the colon, where they can support your gut microbiome and do their work effectively.
Why do the capsules have a slight smell?

You may notice a mild natural scent — that’s the butyrate at work. It’s the same beneficial compound your gut produces naturally.

Can I take this with other medications?

Yes, but we recommend consulting your doctor if you are on medications or have a medical condition.
Can I take this alongside my IBS medications or dietary protocols like low FODMAP?

Yes. This supplement is generally safe alongside most medications and diets. However, always consult your doctor or dietitian, especially if you’re on prescription treatments or restrictive diets.

Are there any side effects?

Most people tolerate this formula well. Some users may notice mild bloating, abdominal sounds or gas in the first couple of weeks — a sign your gut is adjusting.

Individuals with chronic kidney disease, known hypercalcemia, or recurrent kidney stones must use with caution.

Do not exceed the suggested dose. Larger doses than suggested can slow down gut motility and result in constipation.

Is this supplement suitable for vegans or vegetarians?

Yes, the product contains no animal-derived ingredients.

Does this synbiotic contain common IBS triggers like dairy, gluten, or artificial additives?

Our formula is free from dairy, gluten, soy, and artificial colors or sweeteners — all of which can aggravate IBS in some individuals.
Is refrigeration necessary?

Refrigeration is not necessary. You could store the supplement in the fridge if you live in very hot areas.

Which foods contain polyols?

Foods with polyols include apples, stone fruits, mushrooms, and some artificial sweeteners.

Here are some of the most common foods high in polyols:

  • Sorbitol: Stone fruits (like cherries, peaches, plums, nectarines, apricots, and prunes), apples, pears, and blackberries; also used in sugar-free gums, candies, and packaged foods.
  • Mannitol: Cauliflower, mushrooms (black chanterelle, button, enoki, dried porcini, portobello, shiitake), rutabaga, celery, watermelon; also used as a sweetener in sugar-free products.
  • Maltitol: Common in sugar-free chocolates, candies, and baked goods.
  • Xylitol: Found in sugar-free chewing gum, mints, candies, and dental products.
  • Lactitol: Used as a sweetener in sugar-free and reduced-calorie products like ice cream and baked goods.
  • Isomalt: Found in sugar-free candies, throat lozenges, and processed foods as a sugar substitute.
Can I take this if I’m already taking FODZYME®?

Yes. These two products target different sensitivities.FODZYME® breaks down the FODMAPs fructan, GOS, and lactose during digestion, while this synbiotic rebuilds long-term tolerance to polyols (a different FODMAP) by supporting gut microbiome restoration. They can work well together.
What if I miss a dose?

No problem — just pick up where you left off the next day.

If you miss multiple days, consider extending your use slightly before reintroducing polyols.
How do I take it?
  • Take 2 capsules daily with water, preferably with or after a meal
  • Use consistently for at least 8 weeks before testing polyol reintroduction
  • Safe for long-term use unless otherwise advised by your doctor
What happens if I forget to take the supplement?

Consistency (daily use of the suggested dose) is key to boosting your polyol tolerance. If you forget your dose on a certain day, just restart from the next day and give yourself a few additional days towards the 8 week recommended use duration before you start reintroducing polyol containing foods.

How soon will I feel the effects?

You can experiment with your favorite polyol containing foods, starting with a small portion size, after consuming this supplement for at least 4 weeks. Full recovery of polyol metabolic capacity should take about 8 weeks.
Can I take it while pregnant or breastfeeding?

It’s best to consult your healthcare provider before use during pregnancy or lactation.
What is your 30-day risk-free guarantee? Do you accept returns?

If you are not satisfied with your purchase for any reason, you may request a refund within 30 days of delivery of your first order. You’ll receive a full refund for the product cost—less shipping, VAT, and duties—no questions asked.

Please note: Refunds apply to your first order only, not any subsequent shipments.
Do you ship internationally?

Yes! We ship to the following countries:

  • United States
  • Australia
  • New Zealand
  • United Kingdom
  • Canada
  • Belgium
  • Netherlands
  • Poland
  • Austria
  • Germany
  • Czechia
  • Slovakia
  • Switzerland
  • United Arab Emirates
  • Israel
  • France
  • Denmark
  • Italy
  • Finland
  • Norway
  • Sweden

Fructan (a FODMAP) rather than gluten (not a FODMAP) might be the real trigger for those with non-celiac gluten sensitivities.

FODZYME® is gluten-free but does not break down gluten, the protein found in wheat, barley, and rye. However, these grains are also high in the FODMAP fructan, which can cause digestive discomfort for many. In fact, many non-celiacs and individuals without wheat allergies who believe they are sensitive to gluten may actually be reacting to fructans. For those with fructan intolerance, FODZYME® can help improve tolerance to fructan-rich grains like wheat, making them easier to enjoy.

  1. Leibniz-Institut für Lebensmittel-Systembiologie an der TU München. (2020, August 11). Gluten in wheat: What has changed during 120 years of breeding?. ScienceDaily. Retrieved July 19, 2021 from www.sciencedaily.com/releases/2020/08/200811120112.htm
  2. Fedewa, A., & Rao, S. S. (2014). Dietary fructose intolerance, fructan intolerance and FODMAPs. Current gastroenterology reports, 16(1), 370. https://doi.org/10.1007/s11894-013-0370-0 – 4
  3. Schuppan, D., Pickert, G., Ashfaq-Khan, M., & Zevallos, V. (2015). Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best practice & research. Clinical gastroenterology, 29(3), 469–476. https://doi.org/10.1016/j.bpg.2015.04.002
  4. Nordin E., Brunius C., Landberg R., Hellström P.M. Fermentable Oligo-, Di-, Monosaccharides, and Polyols (FODMAPs), but Not Gluten, Elicit Modest Symptoms of Irritable Bowel Syndrome: A Double-Blind, Placebo-Controlled, Randomized Three-Way Crossover Trial. Am. J. Clin. Nutr. 2022;115:344–352. doi: 10.1093/ajcn/nqab337.
  5. Skodje G.I., Sarna V.K., Minelle I.H., Rolfsen K.L., Muir J.G., Gibson P.R., Veierød M.B., Henriksen C., Lundin K.E.A. Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity. Gastroenterology. 2018;154:529–539.e2. doi: 10.1053/j.gastro.2017.10.040.
  6. Lee AR, Wolf RL, Lebwohl B, Ciaccio EJ, Green PHR. Persistent Economic Burden of the Gluten Free Diet. Nutrients. 2019;11(2):399. Published 2019 Feb 14. doi:10.3390/nu11020399
  7. Liu, J., Chey, W. D., Haller, E., & Eswaran, S. (2020). Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn. Annual review of medicine, 71, 303–314. https://doi.org/10.1146/annurev-med-050218-013625
  8. Van den Houte K, Colomier E, Routhiaux K, et al. Efficacy and findings of a blinded randomized reintroduction phase for the low FODMAP diet in Irritable Bowel Syndrome. Gastroenterology. Published online February 22, 2024. doi:10.1053/j.gastro.2024.02.008.
  9. Barone, M., Gemello, E., Viggiani, M. T., Cristofori, F., Renna, C., Iannone, A., Di Leo, A., & Francavilla, R. (2020). Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial. Nutrients, 12(3), 705. https://doi.org/10.3390/nu12030705